Isolate the enzyme that synthesizes folic acid

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Isolate the enzyme that synthesizes folic acid

Assume you isolate the enzyme that synthesizes folic acid in bacteria and conduct some enzyme kinetics experiments. You find, not surprisingly, that sulfa drugs inhibit the enzyme’s activity. What happens to the Vmax and KM of this enzyme when it is treated with sulfa drugs? Why do sulfa drugs have no effect on human metabolism?

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